I look at the chart and pics of other bikes then go for a ride, try to imagine/hold my hands in different positions to 'feel it out, and pretty much end up right back where the oem grips are. My hands and wrists dont get tired, other than the normal hold the throttle open. Any change for me would be so minor as to be not worth the trouble.
Still, that is a GREAT chart for reference!
Try one of these for better leverage on the throttle, can't be without mine :
Also I had some 1" spacers that went under the stock bars, allowed me to angle the ends down a bit more for a better wrist angle without hitting my legs in low speed turns, Traded them out for some Spirit risers I've never installed yet,,, miss the old spacers ...